Metal debris from metal-on-metal (MoM) total hip arthroplasties (THA) has been suspected to\ncause periprosthetic heterotopic ossifications (HO). We determined the influence of disseminated\ncobalt, chromium and molybdenum on the development of HO. Native blood samples from patients\nwith 86 high-carbon and 16 low-carbon Co28Cr6Mo articulations were analysed by highresolution\ninductively coupled plasma mass-spectrometry (HR ICP-MS). The results revealed that\nhigh-carbon metal-on-metal articulations showed lower metal blood levels (Co 1.03 to 1.60 �¼g/l,\nCr 0.77 to 0.88 �¼g/l, Mo 0.45 to 0.56 �¼g/l) whereas low-carbon articulations achieved higher metal\nblood levels (Co 2.59 to 6.85 �¼g/l, Cr 1.25 to 3.55 �¼g/l, Mo 0.45 to 0.64 �¼g/l), but no correlation\nbetween metal ion blood level or carbon content and the development of HO could be found in\nthese MoM articulations. Hence, metal debris from MoM articulation does not stimulate heterotopic\nbone formation despite other well-known local reactions.
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